- #COMPREHENSIVE META ANALYSIS V2 INSTALL#
- #COMPREHENSIVE META ANALYSIS V2 SERIAL#
- #COMPREHENSIVE META ANALYSIS V2 UPGRADE#
Tumor necrosis factor (TNF) - α is one of the most potent proinflammatory cytokines and play a role in tissue injury and induced bone resorption in the immune response system and its coding gene has been mapped to chromosome 6. Therefore, many gene polymorphisms have been investigated 9, 10, 11, 12, 13. Researches indicated nearly half of the clinical differences of periodontal disease rooted from gene polymorphism 8.
With the deepen research of human gene, the more extensive evidence of pathogenesis of periodontitis has been provided 7. Hence, AgP can be considered as a complex genetic disease and the influence of genes and environmental factors determine the individual phenotype corporately 6. Surely, some pathogens are the external initiating factor in the pathogenesis of AgP and the degrees of harm risk are inconsistent, suggesting that host heterogeneity might be a decisive factor in the pathogenesis of AgP 5. Concerning the serious hazards of periodontal tissues of patients with AgP in adolescents, it has widely involved more and more scholars and etiological researches referred to the molecular biology, genetics, microbiology, cell biology and other fields for its complex etiology. In 1999, the new term “aggressive periodontitis” have been proposed to replace the former nomenclature “early-onset periodontitis”, which contained “juvenile periodontitis”, “rapidly progressive periodontitis” and “prepubertal periodontitis” 4. In summary, current evidence demonstrates that TNF-a G-308A polymorphism might be associated with AgP susceptibility, especially in Asians and Caucasians.Īggressive periodontitis (AgP) is featured of the rapid rate of disease progression, onset in healthy individuals without large accumulation of plaque and/or calculus and with genetic familial trait 1, 2, 3. There was no evidence of publication bias. Stratified analyses of confirmed of HWE, Asians, Caucasians and population-based controls obtained results similar to that of overall analysis. Cumulative analysis showed that the association changed from non-significant to significant with new studies accumulated and the CIs became more and more narrow, sensitivity analysis indicated results were statistically robust.
AG+GG genetic models ( OR = 2.09, 95% CI = 1.13–3.86) however, the non-significantly increased risk was shown in AG vs. The meta-analysis showed a significantly increased risk in A vs. 16 case-control studies were searched from the PubMed, Embase and CNKI databases up to February 2, 2015. Please contact us here for special arrangements.Association between tumor necrosis factor-α (TNF-α) G-308A (rs1800629) polymorphism and susceptibility to aggressive periodontitis (AgP) were inconsistent, hence we performed this meta-analysis to clarify the association between them using Comprehensive Meta-Analysis v2.2 software. What if our auditing rules require that we own a perpetual license?Ī. However, we will not be updating the V2 installation for future versions of Windows.
#COMPREHENSIVE META ANALYSIS V2 INSTALL#
If you already have a perpetual license for V2 and need to install it on a new machine, we will send you a link to re-install. Otherwise, your name should match the V2 licenseĪ.
#COMPREHENSIVE META ANALYSIS V2 SERIAL#
If you have your serial number, please provide it. On the order form, check the box for “Upgrade from V2". Pay for a two-year V3 license and get a third year at no additional cost.Ī. Each license operates independently of the other.Ī. The two programs will co-exist on the same machine.
#COMPREHENSIVE META ANALYSIS V2 UPGRADE#
If I have Version 2 and I upgrade to Version 3, can I still keep my Version 2 license?Ī. Any file created in V2 can be used in V3, and vice-versa. Are files from Version 2 and Version 3 compatible with each other?Ī.
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